Enzyme of the Day

Each day Apimba highlights one enzyme from our curated database of biochemical catalysts. The selection is deterministic for the day, so everyone sees the same enzyme until midnight UTC.

cystathionine gamma-synthase

EC Number: 2.5.1.48

Reaction: O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate

Systematic name: O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase

Other names: O-succinyl-L-homoserine succinate-lyase (adding cysteine); O-succinylhomoserine (thiol)-lyase; homoserine O-transsuccinylase (ambiguous); O-succinylhomoserine synthase; O-succinylhomoserine synthetase; cystathionine synthase; cystathionine synthetase; homoserine transsuccinylase (ambiguous); 4-O-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase

Comments: A pyridoxal-phosphate protein. Also reacts with hydrogen sulfide and methanethiol as replacing agents, producing homocysteine and methionine, respectively. In the absence of thiol, can also catalyse beta,gamma-elimination to form 2-oxobutanoate, succinate and ammonia.

CAS Number: 9030-70-0

References: BRENDA, EXPASY, IUBMB, KEGG, PDB

Enzyme of the Day for October 17, 2026. Full view · Search database · Wiki search

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